T- and B- lymphocytes immunophenotype, expression of activation and monocyte’s markers in patients with scleroma were studied. The dependence of these parameters upon the disease clinical form was also established. Monoclonal antibodies to CD3, CD4, CD8, pan-B (CD72), CD14, CD38 and HLA-Dr antigens, antibodies to surface immunoglobulins G, A, M were applied. The changes of immune status of patients with scleroma, which can cause the development of local mononuclear-infiltrative inflammation were revealed. Activation markers expression on peripheral blood and granuloma mononuclears, pan-B+ (CD72+) cells content and expression of surface Ig G, A, M were decreased, especially in patients with atrophic form of scleroma. CD8+ cells amount was increased, especially in patients with cicatrix and infiltrative forms. The increase of CD14+ cells content was also observed in the case of cicatrix scleroma form. The CD4/CD8 ratio, content of CD3+ and CD4+ lymphocytes were decreased. The increase of CD38+ cells number was noted in all scleroma forms, was especially marked in patients, suffering from infiltrative form of scleroma.