Among the group of patients with frequent recurrences of herpetic infection (FRH, HSV I, II) with different localization one patient was revealed torpid to standard therapy. Examining his γ-interferon system (IFNγ) we determined that IFNγ production and expression of IFNγ a-chain receptor were normal but a peripheral blood cell response to the given cytokine estimated by Interleukin 12 production (IL12p70) was reduced. It may due to impaired signaling pathway of IFNγ receptor, caused by HSV and could play an important role in development of chronic infection and resistance to therapy.