CLINICAL IMMUNOLOGY
Effect of perinatal risk factors on neutrophil gelatinase-associated lipocalin (NGAL) level in umbilical and peripheral blood in neonates
Submission date: 2017-05-22
Final revision date: 2017-08-03
Acceptance date: 2017-08-16
Publication date: 2017-10-30
Cent Eur J Immunol 2017;42(3):274-280
KEYWORDS
ABSTRACT
Introduction: Acute kidney injury biomarkers are opening a new era in diagnosing kidney failure. The requirement for a specific and sensitive marker of kidney function is highly desirable in neonates because the diagnostic possibilities in this age group are not sufficient. Recent research show that neutrophil gelatinase-associated lipocalin (NGAL) can have a great potential but there is a wide range of medical conditions, that may influence their expression.
The aim of the study was to evaluate the impact of perinatal risk factors on NGAL level in neonates.
Material and methods: NGAL was measured in umbilical cord blood and peripheral blood in full term neonates with perinatal risk factors during the first days of life.
Results: We found significantly higher umbilical cord blood NGAL levels in neonates with perinatal risk factors (117.69 ng/ml) compared to the control group (64.37 ng/ml). No significant difference in peripheral blood NGAL level was shown between the two groups. Umbilical cord blood NGAL level correlated positively with peripheral blood NGAL level (r = 0.36, p < 0.01). Umbilical cord blood NGAL level was significantly higher in neonates with fetal distress and infection compared to neonates with other perinatal risk factors. Peripheral blood NGAL level was significantly higher in neonates with infection compared to neonates with other perinatal risk factors. Significantly higher umbilical cord blood NGAL levels were seen in neonates born by operative delivery compared to born by natural delivery.
The aim of the study was to evaluate the impact of perinatal risk factors on NGAL level in neonates.
Material and methods: NGAL was measured in umbilical cord blood and peripheral blood in full term neonates with perinatal risk factors during the first days of life.
Results: We found significantly higher umbilical cord blood NGAL levels in neonates with perinatal risk factors (117.69 ng/ml) compared to the control group (64.37 ng/ml). No significant difference in peripheral blood NGAL level was shown between the two groups. Umbilical cord blood NGAL level correlated positively with peripheral blood NGAL level (r = 0.36, p < 0.01). Umbilical cord blood NGAL level was significantly higher in neonates with fetal distress and infection compared to neonates with other perinatal risk factors. Peripheral blood NGAL level was significantly higher in neonates with infection compared to neonates with other perinatal risk factors. Significantly higher umbilical cord blood NGAL levels were seen in neonates born by operative delivery compared to born by natural delivery.
REFERENCES (29)
1.
Selewski DT, Charlton JR, Jetton JG, et al. (2005): Neonatal Acute Kidney Injury. Pediatrics 136: e463-e473.
2.
Andreoli SP. (2004): Acute renal failure in the newborn. Semin Perinatol 28: 112-123.
3.
Cataldi L, Leone R, Moretti U, et al. (2005) Potential risk factors for the development of acute renal failure in preterm newborn infants: a case-control study. Arch Dis Child Fetal Neonatal Ed 90: F514-F519.
4.
Iacobelli S, Bonsante F, Ferdinus C, et al. (2009): Factors affecting postnatal changes in serum creatinine in preterm infants with gestational age < 32 weeks. J Perinatol 29: 232-236.
5.
Cuzzolin L, Fanos V, Pinna B, et al. (2006): Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions. Pediatr Nephrol 21: 931-938.
6.
Karlowicz MG, Adelman RD (1995): Nonoliguric and oliguric acute renal failure in asphyxiated term neonates. Pediatr Nephrol 9: 718-722.
7.
Guignard JP, Drukker A (1999): Why do newborn infants have a high plasma creatinine? Pediatrics 103: e49.
8.
Askenazi DJ, Ambalavanan N, Goldstein SL (2009): Acute kidney injury in critically ill newborns: what do we know? What do we need to learn? Pediatr Nephrol 24: 265-274.
9.
Sarafidis K, Tsepkentzi E, Agakidou E, et al. (2012): Serum and urine acute kidney injury biomarkers in asphyxiated neonates. Pediatr Nephrol 27: 1575-1582.
10.
Askenazi DJ, Montesanti A, Hunley H, et al. (2011): Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants. J Pediatr 159: 907-912.
11.
Askenazi DJ, Koralkar R, Hundley HE, et al. (2012): Urine biomarkers predict acute kidney injury in newborns. J Pediatr 161: 270-275.
12.
Singer E, Elger A, Elitok S, et al. (2011): Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int 80: 405-414.
13.
Pejovic B, Eric-Marinkovic J, Pejovic M, et al. (2015): Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL)-sensitivity and specificity of a potential new biomarker. Biochem Med (Zagreb) 25: 450-459.
14.
Raggal NE, Khafagy SM, Mahmoud NH, et al. (2013): Serum neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in asphyxiated neonates. Indian Pediatr 50: 459-462.
15.
Parravicini E, Nemerofsky SL, Michelson KA, et al. (2010): Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants. Pediatr Res 67: 636-640.
16.
Inoue H, Ohga S, Kusuda T, et al. (2013): Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Early Hum Dev 89: 425-429.
17.
Krawczeski CD, Woo JG, Wang Y, et al. (2011): Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. J Pediatr 158: 1009-1015.
18.
Essajee F, Were F, Admani B (2015): Urine neutrophil gelatinase-associated lipocalin in asphyxiated neonates: a prospective cohort study. Pediatr Nephrol 30: 1189-1196.
19.
Lavery AP, Meinzen-Derr JK, Anderson E, et al. (2008): Urinary NGAL in premature infants. Pediatr Res 64: 423-428.
20.
Huynh TK, Bateman DA, Parravicini E, et al. (2009): Reference values of urinary neutrophil gelatinase-associated lipocalin in very low birth weight infants. Pediatr Res 66: 528-532.
21.
Saeidi B, Koralkar R, Griffin RL, et al. (2015): Impact of gestational age, sex, and postnatal age on urine biomarkers in premature neonates. Pediatr Nephrol 30: 2037-2044.
22.
Surmiak P, Baumert M, Fiala M, et al. (2014): Umbilical cord blood NGAL concentration as an early marker of perinatal asphyxia in neonates. Ginekol Pol 85: 424-427.
23.
Chen C-N, Chou C-H, Jeng S-F, et al. (2016): Urinary Neutrophil Gelatinase-Associated Lipocalin Levels in Neonates. Pediatr Neonatol 57: 207-212.
24.
Tadesse S, Luo G, Park JS, et al. (2011): Intra-amniotic infection upregulates neutrophil gelatinase-associated lipocalin (NGAL) expression at the maternal-fetal interface at term: implications for infection-related preterm birth. Reprod Sci 18: 713-722.
25.
Medic B, Rovcanin B, Vujovic KS, et al. (2016): Evaluation of novel biomarkers of acute kidney injury: the possibilities and limitations. Curr Med Chem 23(: 1981-1997.
26.
Suchojad A, Tarko A, Smertka M, et al. (2015): Factors limiting usefulness of serum and urinary NGAL as a marker of acute kidney injury in preterm newborns. Ren Fail 37: 439-445.
27.
Al-Ismaili Z, Palijan A, Zappitelli M (2011): Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application. Pediatr Nephrol 26: 29-40.
28.
Sim JH, Yim HE, Choi BM, et al. (2015): Plasma neutrophil gelatinase-associated lipocalin predicts acute pyelonephritis in children with urinary tract infections. Pediatr Res 78: 48-55.
29.
Otto GP, Hurtado-Oliveros J, Chung H-Y, et al. (2015): Plasma Neutrophil Gelatinase-Associated Lipocalin Is Primarily Related to Inflammation during Sepsis: A Translational Approach. PLoS One 10: e0124429.
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