CLINICAL IMMUNOLOGY
Can mean platelet volume and neutrophil-to-lymphocyte ratio be biomarkers of acute exacerbation of bronchiectasis in children?
Submission date: 2016-08-05
Final revision date: 2016-12-06
Acceptance date: 2016-12-12
Publication date: 2017-12-30
Cent Eur J Immunol 2017;42(4):358-362
KEYWORDS
ABSTRACT
Introduction: Bronchiectasis (BE) is a parenchymal lung disease evolving as a result of recurrent lung infections and chronic inflammation. Although it has been shown in adult studies that mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) can be used as biomarkers of airway inflammation, knowledge is limited in the paediatric age group. The aim of our study is to investigate the potential of MPV and NLR as biomarkers that may indicate acute exacerbations of non-cystic fibrosis BE in children.
Material and methods: Children with non-cystic fibrosis BE (n = 50), who were followed in the division of Paediatric Pulmonology of our hospital between June 2010 and July 2015, were involved in the present retrospective cross-sectional study. Haemogram values during acute exacerbations and non-exacerbation periods, and a control group were compared.
Results: In children with bronchiectasis, the average leukocyte count (p < 0.001), platelet count
(p = 0.018), absolute neutrophil count (p < 0.001), and NLR (p < 0.001) were higher, as expected, when compared with the control group. NLR values, in the period of acute exacerbation were significantly higher than the values of both the non-exacerbation periods (p = 0.02) and the control group (p < 0.001). In contrast, MPV values in the period of acute exacerbation did not exhibit a significant difference from those of non-exacerbation periods (p = 0.530) and the control group (p = 0.103).
Conclusions: It was concluded that leukocyte count, platelet count, absolute neutrophil count, and NLR can be used to show chronic inflammation in BE, but only NLR and absolute neutrophil count can be used as biomarkers to show acute exacerbations.
Material and methods: Children with non-cystic fibrosis BE (n = 50), who were followed in the division of Paediatric Pulmonology of our hospital between June 2010 and July 2015, were involved in the present retrospective cross-sectional study. Haemogram values during acute exacerbations and non-exacerbation periods, and a control group were compared.
Results: In children with bronchiectasis, the average leukocyte count (p < 0.001), platelet count
(p = 0.018), absolute neutrophil count (p < 0.001), and NLR (p < 0.001) were higher, as expected, when compared with the control group. NLR values, in the period of acute exacerbation were significantly higher than the values of both the non-exacerbation periods (p = 0.02) and the control group (p < 0.001). In contrast, MPV values in the period of acute exacerbation did not exhibit a significant difference from those of non-exacerbation periods (p = 0.530) and the control group (p = 0.103).
Conclusions: It was concluded that leukocyte count, platelet count, absolute neutrophil count, and NLR can be used to show chronic inflammation in BE, but only NLR and absolute neutrophil count can be used as biomarkers to show acute exacerbations.
REFERENCES (31)
1.
Re Redding GJ (2009): Bronchiectasis in children. Pediatr Clin North Am 56: 157-171.
2.
Karadag B, Karakoc F, Ersu R, et al. (2005): Non-cystic fibrosis bronchiectasis in children: a persisting problem in developing countries. Respiration 72: 233-238.
3.
Wilson CB, Jones PW, O’Leary CJ, et al. (1997): Validation of the St. George’s respiratory questionnaire in bronchiectasis. Am J Respir Crit Care Med 156: 536-541.
4.
Bloemen K, Van Den Heuvel R, Govarts E, et al. (2011): A new approach to study exhaled proteins as potential biomarkers for asthma. Clin Exp Allergy 41: 346-356.
5.
van de Kant KD, Jansen MA, Klaassen EM, et al. (2012): Elevated inflammatory markers at preschool age precedepersistent wheezing at school age. Pediatr Allergy Immunol 23: 259-264.
6.
Wiwanitkit V (2004): Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin Appl Thromb Hemost 10: 175-178.
8.
B-thromboglobulin and platelet factor in bronchoalveolar lavage fluid of patients with systemic sclerosis. Ann Rheum Dis 64: 484-486.
9.
Yamamoto H, Nagata M, Tabe K, et al. (1993): The evidence of platelet activation in bronchial asthma. J Allergy Clin Immunol 91: 79-87.
10.
Agustí AG, Noguera A, Sauleda J, et al. (2003): Systemic effects of chronic obstructive pulmonary disease. Eur Respir J 21: 347-360.
11.
Chang AB, Reddind GJ (2006): Bronchiectasis. In: Chernick V, Boat T, Wilmott RW, Bush A, Kendig EL, editors. Kendig’s disorders of respiratory tract in children. Philadelphia: WB Saunders Company; 463-476.
12.
Khandekar MM, Khurana AS, Deshmukh SD, et al. (2006): Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 59: 146-149.
13.
Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP (2003): Trombosits as predictors of vascular risk: Is there a practical index of trombosit activity? Clin Appl Thromb Hemost 9: 177-190.
14.
Bath PM, Butterworth RJ (1996): Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 7: 157-161.
15.
Idzko M, Pitchford S, Page C (2015): Role of platelets in allergic airway inflammation. J Allergy Clin Immunol 135: 1416-1423.
16.
Bansal R, Gupta HL, Goel A (2002): Association of Increased Platelet Volume In Patients of Chronic Obstructive Pulmonary Disease: Clinical Implications. JIACM 40: 104-107.
17.
Erden ES, Dokuyucu R, Demirköse M, et al. (2013): Assessment of mean platelet volume in chronic obstructive pulmonary disease during stable period and acute exacerbation. JCEI 4: 483-487.
18.
Steiropoulos P, Papanas N, Nena E, et al. (2013): Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease: the role of comorbidities. Angiology 64: 535-539.
19.
Uysal P, Tuncel T, Erge D, et al. (2014): Does Mean Platelet Volume in Children with Bronchiectasis Predict Exacerbations? Int J Hematol Oncol 24: 54-59.
20.
Tuncel T, Uysal P, Hocaoglu AB, et al. (2012): Change of mean platelet volume values in asthmatic children as an inflammatory marker. Allergol Immunopathol (Madr) 40: 104-107.
21.
Nacarog¡lu HT, I•şgüder R, Bahceci SE, et al. (2016): Can mean platelet volume be used as a biomarker for asthma? Postepy Dermatol Alergol 33: 182-187.
22.
Bhat T, Teli S, Rijal J, et al. (2013): Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 11: 55-59.
23.
Zahorec R. (2001): Ratio of neutrophil to lymphocyte counts – Rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 102: 5-14.
24.
Rohde G, Borg I, Wiethege A, et al. (2008): Inflammatory response in acute viral exacerbations of COPD. Infection 36: 427-433.
25.
Ulasli SS, Ozyurek BA, Yilmaz EB, Ulubay G. (2012): Mean platelet volume as an inflammatory marker in acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Med Wewn 122: 284-290.
26.
Saldias PF, Diaz PO, Dreyse DJ, et al. (2012): Etiology and biomarkers of systemic inflammation in mild to moderate COPD exacerbations. Rev Med Chil 140: 10-18.
27.
Drews AC, Pizzichini MM, Pizzichini E, et al. (2009): Neutrophilic airway inflammation is a main feature of induced sputum in nonatopic asthmatic children. Allergy 64: 1597-1601.
28.
Zhang XY, Simpson JL, Powell H, et al. (2014): Full blood count parameters for the detection of asthma inflammatory phenotypes. Clin Exp Allergy 44: 1137-1145.
29.
Furukawa T, Sakagami T, Koya T, et al. (2015): Characteristics of eosinophilic and non-eosinophilic asthma during treatment with inhaled corticosteroids. J Asthma 52: 417-422.
30.
Fu JJ, Baines KJ, Wood LG, Gibson PG (2013): Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. OMICS 17: 187-199.
31.
Günay E, Sarnç Ulaşl S, Akar O, et al. (2014): Neutrophil-to-lymphocyte ratio in chronic obstructive pulmonary disease: a retrospective study. Inflammation 37: 374-380.
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