CLINICAL IMMUNOLOGY
Levels of cytokines in drug hypersensitivity
Submission date: 2016-04-06
Final revision date: 2016-10-24
Acceptance date: 2017-01-10
Publication date: 2017-12-30
Cent Eur J Immunol 2017;42(4):354-357
KEYWORDS
ABSTRACT
Introduction: Multiple drug intolerance is a serious complication of drug therapy and is an issue of allergology. The aim of the study was the investigation of cytokine status in patients with drug hypersensitivity and multiple drug hypersensitivity.
Material and methods: 19 patients with multiple drug hypersensitivity, 34 patients with hypersensitivity to one drug, and 35 non-allergic subjects were involved. Only women were included in the study. A multiplex assay of 27 cytokines and chemokines was performed using xMap technology (Human Cytokine Panel I by Bio-Rad).
Results: Women with drug allergy revealed increased IL-2 levels (p < 0.05). In the case of the study of cytokine status in patients with multiple drug hypersensitivity, the new data revealed the prevalence of pro-inflammatory cytokine status with the participation of cytokines IL-17, IL-9, TNF-α, IP-10, and MIP-1.
Conclusions: Various immune response arms Th2, Th17, as well as macrophages were the determining factors in the cytokine balance that was found in patients with multiple drug hypersensitivity.
Material and methods: 19 patients with multiple drug hypersensitivity, 34 patients with hypersensitivity to one drug, and 35 non-allergic subjects were involved. Only women were included in the study. A multiplex assay of 27 cytokines and chemokines was performed using xMap technology (Human Cytokine Panel I by Bio-Rad).
Results: Women with drug allergy revealed increased IL-2 levels (p < 0.05). In the case of the study of cytokine status in patients with multiple drug hypersensitivity, the new data revealed the prevalence of pro-inflammatory cytokine status with the participation of cytokines IL-17, IL-9, TNF-α, IP-10, and MIP-1.
Conclusions: Various immune response arms Th2, Th17, as well as macrophages were the determining factors in the cytokine balance that was found in patients with multiple drug hypersensitivity.
REFERENCES (23)
1.
Asero R (2001): Multiple drug allergy syndrome: a distinct clinical entity. Curr Allergy Rep 1: 18-22.
2.
Gex-Collet C, Helbling A, Pichler W (2005): Multiple Drug Hypersensitivity – proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests. J Invest Allergol Clin Immunol 4: 293-296.
3.
Macy E, Ho NJ (2012): Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management. Ann Allergy Asthma Immunol 2: 88-93.
4.
Anahita FD (2012): Management of Multiple Drug Allergies in Children. Curr Allergy Asthma Rep 12: 79-84.
5.
Akhmaltdinova L, Starikova S (2011): Clinical epidemiology of drug allergy. Int J Immunopathol Allergol Infectiol 4: 24-26.
6.
Langen U, Schmitz R, Steppuhn H (2013): Prevalence of allergic diseases in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56: 698-706.
7.
Dońa I, Blanca-Lopez N, Torres MJ, et al. (2012): Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients. J Investig Allergol Clin Immunol 22: 363-71.
8.
Houser B (2012): Bio-Rad’s Bio-Plex® suspension array system, xMAP technology overview. Arch Physiol Biochem 118: 192-196.
9.
Kaplan A, Kuna P, Reddigari S (1995): Chemokines and the allergic response. Exp Dermatol 4: 260-265.
10.
Romagnani S (2002): Cytokines and chemoattractants in allergic inflammation. Mol Immunol 38: 881-885.
12.
Wisniewski J, Borish L (2011): Novel cytokines and cytokine-producing T cells in allergic disorders. Allergy Asthma Proc 32: 83-94.
13.
Bhakta N, Woodruff P (2011): Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev 242: 220-232.
14.
Boonpiyathad S, Pornsuriyasak P, Buranapraditkun S, et al. (2013): Interleukin-2 levels in exhaled breath condensates, asthma severity, and asthma control in nonallergic asthma. Allergy Asthma Proc 34: 35-41.
15.
Lin TY, Venkatesan N, Mahboub B, et al. (2013): Involvement of lymphocytes in asthma and allergic diseases: a genetic point of view. Curr Opin Allergy Clin Immunol 13: 500-506.
16.
Zhao P, Xiao X, Ghobrial RM, et al (2013): IL-9 and Th9 cells: progress and challenges. Int Immunol 5: 547-551.
17.
Bhakta N, Woodruff P (2011): Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev 42: 220-232.
18.
Herbert C, Shadie A, Kumar R (2013): Interleukin-17 Signalling in a Murine Model of Mild Chronic Asthma. Int Arch Allergy Immunol 162: 253-262.
19.
Ishioka T, Yamada Y, Kimura H, et al. (2013): Elevated macrophage inflammatory protein 1 and interleukin-17 production in an experimental asthma model infected with respiratory syncytial virus. Int Arch Allergy Immunol 2: 129-137.
20.
Glez P, Franco Y, Matheu V (2012): MIP-1, MCP-1, and desensitization in anaphylaxis from cow’s milk. N Engl J Med 367: 282-284.
21.
Tworek D, Kuna P, Młynarski W, et al. (2013): MIG (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11) concentrations after nasal allergen challenge in patients with allergic rhinitis. Arch Med Sci 9: 849-853.
22.
Desai D, Brightling C (2010): TNF-αlpha antagonism in severe asthma? Recent Pat Inflamm Allergy Drug Discov 4: 193-200.
23.
Brightling C, Berry M, Amrani Y (2008): Targeting TNF-αlpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 121: 5-10.
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