Experimental immunology
Diminished reactive oxygen intermediates (ROI) production, decreased the T suppressor cells number and increased cytokine production constitute outline of the lichen sclerosus pathogenesis
Diminished reactive oxygen intermediates (ROI) production, decreased the T suppressor cells number and increased cytokine production constitute outline of the lichen sclerosus pathogenesis
Publication date: 2004-01-20
Cent Eur J Immunol 2003;28(1):1-5
KEYWORDS
ABSTRACT
The involution of lichen sclerosus (LS) affected tissues may be the effect of suppression exerted by T lymphocytes which are involved in the pathogenesis of this disease. Inflammatory infiltrates in the affected regions of the skin consist mainly of CD3+ lymphocytes consist with diminished number of CD3+/CD26+ subsets. We revealed the diminished ROI production by peripheral blood, granulocytes after receptor dependent and receptor independent stimulation. The diminished number both of CD3+/CD25+ and CD3+/CD26+ in peripheral blood baseline increase of IL-12 and stimulated increase of IL-2, IL-5, IL-10 and TNF-α production by peripheral blood lymphocytes were also noted. We postulate that immunereactions are involved in LS pathogenesis.
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| eISSN: | 1644-4124 |
| ISSN: | 1426-3912 |
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