The review briefly describes chosen genes coding for the host innate immunity to staphylococcal infections. There is little known about pathogen – host interactions in such infections. We focus our attention on particular proteins connected with an innate immunity to Staphylococcus aureus during its fundamental steps – pathogen recognition, chemotaxis and immune response regulation process as well as intracellular persistence. Of particular importance is to describe whether mutations, localized in genes, involved in a response to gram-positive bacteria can underlay development of a persistent infection.