Primary antibody deficiencies have variable autoimmune manifestations. Immunodeficiency and A national project with the aims of building up a Polish national registry of primary immunodeficiency diseases (PID), harmonizing existing Polish diagnostic guidelines based on the ESID proposal, developing therapeutic guidelines at a national level, improving patient care in Poland, and raising awareness of PID across the country, was initiated by the Polish Working Group for PID, established in March 2005. The Group has been assembled from six main Polish centres for the diagnosis and therapy for PID. The project has been supported by grant PBZ-KBN-119/P05/04 from the Polish Ministry of Science, and European Union grant EURO-POLICY-PID SP23-CT-2005-006411, both granted since 2005 through 2008.