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Glutaminolysis as a metabolic checkpoint of protective Th1/Th17 immunity against Mycobacterium tuberculosis
1
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland
2
Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland
3
Centre of Regenerative Medicine, Medical University of Bialystok, Bialystok, Poland
4
Tissue and Cell Bank, Medical University of Bialystok Clinical Hospital, Bialystok, Poland
Publication date: 2026-07-28
Cent Eur J Immunol 2026;51(2):109-110
REFERENCES (7)
1.
Cai X, Yidan H, Zeng L, Rong R (2026): Glutaminase 1-mediated glutaminolysis regulates tuberculosis progression by modulating Th1 and Th17 immune responses. Cent Eur J Immunol 2: 121-132.
2.
Johnson MO, Wolf MM, Madden MZ, et al. (2018): Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism. Cell 175: 1780-1795.e19.
3.
Fu J, Pu Y, Wang B, et al. (2022): Pharmacological Inhibition of glutaminase 1 normalized the metabolic state and CD4+ T cell response in Sjogren’s syndrome. J Immunol Res 2022: 3210200.
4.
Koeken VACM, Lachmandas E, Riza A, et al. (2019): Role of glutamine metabolism in host defense against Mycobacterium tuberculosis infection. J Infect Dis 219: 1662-1670.
5.
Yu J, Yan N, Gong Z, et al. (2024): Mycobacterium manipulate glutaminase 1 mediated glutaminolysis to regulate macrophage autophagy for bacteria intracellular survival. Cell Signal 124: 111422.
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Jin L, Ding M, Cui S, et al. (2025): Aberrant glucose metabolism drives dysfunction of CD4. Cent Eur J Immunol 50: 13-23.
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Wang Z, Wang H, Wang Q, et al. (2024): Transcriptome analysis of anaerobic glycolysis effects on Jurkat T cell proliferation. Cent Eur J Immunol 49: 194-202.
| eISSN: | 1644-4124 |
| ISSN: | 1426-3912 |
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