The aim of this study was to examine the effect of iron on IL-1a and IL-6 production. Moreover, the proliferative response of lymphocytes, the metabolic activity of phagocyting cells, the lysozyme activity and g-globulins level were examined in mice peripheral blood.
The experiments were performed on NRMI mice, which were intraperitoneally injected with 0.5 ml: NaCl (control), 150 mg Fe, or 300 mg Fe per body weight, in the form of iron chloride solution.
The results showed that iron decreased statistically significantly IL-1a concentration in mouse serum after injection of both iron doses. No differences between control and experimental groups were observed in other studied parameters.