Candida-associated denture stomatitis constitutes a very important health problem because fungal infections occur in patients who use prosthetic restorations. Increasing resistance of fungi as well as toxicity of antifungals and high costs of treatment have an influence on many difficulties in denture stomatitis treatment. The study was to estimate in vitro susceptibility to the selected antifungal – posaconazole of yeast-like fungal strains, obtained from direct oral mucosal swabs taken from patients using prosthetic restorations. Mycological tests were performed using the method of direct swab taken from oral mucosa. In the next part of the research, cultured strains were identified. Evaluation of susceptibility
of all isolates to posaconazole was estimated using E-test. On the basis of laboratory mycological tests performed, the growth of 99 species of yeast-like fungi was diagnosed at 84.95% among 93 patients, from whom oral mucosa swab samples were collected. Posaconazole presented a high activity against the tested fungal strains.