Clinical immunology
Recombinant human interleukin receptor antagonist influences serum chemokines in patients with rheumatoid arthritis
Recombinant human interleukin receptor antagonist influences serum chemokines in patients with rheumatoid arthritis
Submission date: 2014-04-07
Acceptance date: 2014-05-06
Publication date: 2014-06-27
Cent Eur J Immunol 2014;39(2):170-173
KEYWORDS
ABSTRACT
Objective: To investigate the serum expressions of chemokines CCL2 and CCL3 in patients with rheumatoid arthritis (RA) who were treated with recombinant human interleukin 1 (IL-1) receptor antagonist (IL-1Ra).
Material and methods: Serum CCL2 and CCL3 were determined using an enzyme-linked immunosorbent assay in 54 active RA patients before and after treatment with IL-1Ra or a placebo, as well as 36 healthy controls.
Results: Compared with the healthy controls, all the 54 RA patients exhibited higher serum CCL2 and CCL3 before and after treatment (p < 0.05). However, patients who had a good response to IL-1Ra treatment had significantly lower mean changes in the serum CCL2 and CCL3 levels from baseline to the last injection than IL-1Ra non-responders (p < 0.01).
Conclusions: CCL2 and CCL3 may be useful efficacy markers of IL-1Ra treatment.
Material and methods: Serum CCL2 and CCL3 were determined using an enzyme-linked immunosorbent assay in 54 active RA patients before and after treatment with IL-1Ra or a placebo, as well as 36 healthy controls.
Results: Compared with the healthy controls, all the 54 RA patients exhibited higher serum CCL2 and CCL3 before and after treatment (p < 0.05). However, patients who had a good response to IL-1Ra treatment had significantly lower mean changes in the serum CCL2 and CCL3 levels from baseline to the last injection than IL-1Ra non-responders (p < 0.01).
Conclusions: CCL2 and CCL3 may be useful efficacy markers of IL-1Ra treatment.
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| eISSN: | 1644-4124 |
| ISSN: | 1426-3912 |
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