EXPERIMENTAL IMMUNOLOGY
A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients
Submission date: 2016-01-25
Final revision date: 2016-02-09
Acceptance date: 2016-02-10
Publication date: 2016-03-24
Cent Eur J Immunol 2016;41(1):25-30
KEYWORDS
ABSTRACT
Sarcoidosis is a systemic inflammatory disease with abnormally high angiogenic activity of inflammatory cells. Reumaherb preparation consisting of three herbs: Echinacea purpurea, Harpagophytum procumbens, and Filipendula ulmaria, and it exerts anti-inflammatory, antioxidant, and analgesic activity and stimulates regenerative and immunological processes.
The aim of this paper was to estimate the effect of Reumaherb on immunological angiogenesis induced by bronchoalveolar lavage (BAL) cells collected from six patients with sarcoidosis and grafted into Balb/c mice skin. After grafting, the animals were fed for three days with 0.6 or 1.2 mg of Reumaherb (calculated from recommended human daily dose) daily, suspended in 40 µl of water, or 40 µl of water alone (control group).
A significant reduction of newly formed blood vessels was obtained in four cases for 1.2 mg and in three cases for 0.6 mg daily dose of this remedy. Thus, we hypothesise that Reumaherb promotes anti-angiogenic activity and may potentially be used in diseases associated with excessive blood vessel formation.
The aim of this paper was to estimate the effect of Reumaherb on immunological angiogenesis induced by bronchoalveolar lavage (BAL) cells collected from six patients with sarcoidosis and grafted into Balb/c mice skin. After grafting, the animals were fed for three days with 0.6 or 1.2 mg of Reumaherb (calculated from recommended human daily dose) daily, suspended in 40 µl of water, or 40 µl of water alone (control group).
A significant reduction of newly formed blood vessels was obtained in four cases for 1.2 mg and in three cases for 0.6 mg daily dose of this remedy. Thus, we hypothesise that Reumaherb promotes anti-angiogenic activity and may potentially be used in diseases associated with excessive blood vessel formation.
REFERENCES (23)
1.
Baughman RP, Culver DA, Judson MA (2011): A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med 183: 573-581.
2.
Zielonka TM (2009): Angiogenesis in interstitial lung diseases. Pneumonol Alergol Pol 77: 52-60.
3.
Zielonka TM, Demkow U, Białas B, et al. (2007): Modulatory effect of sera from sarcoidosis patients on mononuclear cells-induced angiogenesis. J Physiol Pharmacol 58 (suppl. 5): 753-766.
4.
Skopińska-Różewska E, Sommer E, Bałan B, et al. (2010): The in vivo effect of dry hydro-alcoholic extract of Echinacea purpurea on angiogenic activity of human blood mononuclear cells. Cent Eur J Immunol 35: 223-226.
5.
Radomska-Leśniewska DM, Demkow U, Chorostowska-Wynimko J, et al. (2006): Immunotropowe działanie złożonego preparatu roślinnego Reumaherb. In: Naturalne i syntetyczne modulatory odpowiedzi immunologicznej i angiogenezy (materiały konferencyjne). Siwicki A, Skopińska-Różewska E (eds.). SPW Edycja, Olsztyn 2006; 49-59.
6.
Radomska-Leśniewska DM, Skopiński P, Bałan BJ, et al. (2015): Angiomodulatory properties of Rhodiola spp. and other natural antioxidants. Cent Eur J Immunol 40: 249-262.
7.
John M, Oltmans U, Fietze I, Witt C (2001): Increased production of matrix metalloproteinase-2 in alveolar macrophages and regulation by interleukine-10 in patients with acute pulmonary sarcoidosis. Exp Lung Res 68: 55-67.
8.
Radomska-Leśniewska DM, Sobiecka M, Chorostowska-Wynimko J, et al. (2003): Relationship between IL-8, IL-10 and MMP-9 level and morphological pattern of BAL fluid in interstitial lung diseases patients. Cent Eur J Immunol 28: 155-159.
9.
Sidky YA, Auerbach R (1975): Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs-host reaction. J Exp Med 141: 1084-1100.
10.
Skopińska-Różewska E, Sommer E, Demkow U, et al. (1997): Screening of angiogenesis inhibitors by modified tumor-induced angiogenesis (TIA) test in lung cancer. Acta Medica Bialostociensis 42: 287-296.
11.
Chorostowska-Wynimko J, Skopińska-Różewska E, Rogala E, et al. (1998): NON-CD4+ and NON-CD8+ cells are the main source of angiogenic activity of BAL cells homogenates from sarcoidosis patients. Eur Respir J 12 (suppl. 28): 332.
12.
He H, Xu J, Warren CM, et al. (2012): Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood 120: 3152-3162.
13.
Martinez FO, Gordon S (2014): The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep 6: 13.
14.
Liu Y, Zou X, Chai Y, Yao Y (2014): Macrophage polarization in inflammatory diseases. Int J Biol Sci 10: 520-530.
15.
Tolnay E, Kuhnen C, Voss B, et al. (1998): Expression and localization of vascular endothelial growth factor and its receptor in pulmonary sarcoidosis. Virchows Arch 432: 61-65.
16.
Matsuda M, Sakurai K, Fushimi T, et al. (2004): Sarcoidosis with high serum levels of vascular endothelial growth factor (VEGF) showing RS3PE-like symptoms in extremities. Clin Rheum 2004; 23: 246-248.
17.
Skopińska-Różewska E, Pastewka K, Wasiutyński A, et al. (2010): The influence of herbal remedies on cutaneous angiogenesis induced in mice after grafting of human kidney cancer tissue. Centr Eur J Immunol 35: 199-203.
18.
Rogala E, Skopińska-Różewska E, Wasiutyński A, et al. (2008): Echinacea purpurea diminishes neovascular reaction induced in mice skin by human cancer cells and stimulates non-specific cellular immunity in humans. Centr Eur J Immunol 33: 127-130.
19.
Wasiutyński A, Bałan B, Skopińska-Różewska E, et al. (2009): The effect of Echinacea purpurea on the morphology, angiogenic activity and vascular endothelial growth factor (VEGF) concentration of murine L-1 sarcoma tumors. Cent Eur J Immunol 34: 38-41.
20.
Radomska-Leśniewska D, Demkow U, Sommer E, (2003): Wpływ destylatu borowiny limanu z dodatkiem kwasu cynamonowego i kumaryny (FIBS) na aktywność angiogenną komórek pochodzących od chorych na sarkoidozę. In: Rola immunomodulatorów pochodzenia naturalnego w zapobieganiu i leczeniu chorób. Siwicki A, Skopińska-Różewska E, (eds.). Wyd. Medyk, Warszawa 2003; 229-236.
21.
Skopiński P, Sommer E, Skopińska-Różewska E, et al. (2001): The effect of coastal salt lake mud distillate mixed with cinnamic acid and coumarin (FIBS) on immunological and inflammatory angiogenesis. Terapia 3: 14-15.
22.
Radomska-Leśniewska DM, Skopińska-Różewska E, Jankowska-Steifer E, et al. (2010): N-acetylcysteine inhibits IL-8 and MMP-9 release and ICAM-1 expression by bronchoalveolar cells from interstitial lung diseases patients. Pharmacol Rep 62: 131-138.
23.
Radomska-Leśniewska DM, Skopiński P (2012): N-acetylcysteine as an antioxidant and antiinflammatory drug and its some clinical application. Cent Eur J Immunol 37: 57-66.
Share
RELATED ARTICLE
| eISSN: | 1644-4124 |
| ISSN: | 1426-3912 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
