The aim of this study was to examine the effect of chromium on interleukine 1α and 6 (IL-1α and IL-6 production. Moreover, the proliferative response of lymphocytes, the metabolic activity of phagocyting cells, the lysozyme activity and g-globulins level were examined. The experiments were performed on NRMI mice, which were intraperitoneally injected with 0,5 ml: NaCl (control), 1 or 10 mg Cr per body weight, which was administered in the form of chromium chloride solution. The present study has shown that chromium decreases statistically significantly IL-1α concentration after injection of chromium at a dose of 1 and 10 mg Cr per body weight. The concentration of IL-6 does not differ from the control group in both experimental groups. We have observed no differences in the proliferative response of lymphocytes and in the metabolic activity of phagocyting cells. Similar results have been observed in lysozyme and γ-globulins levels.