Malaria is an important tropical infection. Development and approval of new vaccines are the hope for infectious control of the possible emerging pandemic of this pathogen. Malarial VAR2CSA may have value as a protective immunogen in novel vaccines. Here, the author reports the preliminary data from the computation analysis of VAR2CSA to find potential T-cell and B-cell epitopes using new bioinformatics tools. According to this work, the possible alternatives are reported. These data are useful for further vaccine development because these promiscuous peptide binders allows to minimize the total number of predicted epitopes without compromising the population coverage required in the design of vaccines.