We previously reported that single enoxaparine dose administered prior to the hip surgery resulted in an increase of angiogenic activity and basic fibroblast growth factor (bFGF) level in patients’ sera without any corresponding alterations in the vascular endothelial growth factor (VEGF) concentration. Increased VEGF serum level, however, was observed in sera after 14 enoxaparine injections. Plasminogen activator inhibitor-1 (PAI-1) levels increased after single enoxaparine dose, and no significant alterations in plasma VEGF, fibrinogen and antithrombin III (AT-III) levels were seen. In the present paper we have study the same parameters in plasma of patients treated with enoxaparine for 2 weeks after surgery. Significant increase of plasma PAI-1 and fibrinogen concentration, as well as angiogenic plasma activity in vivo in PIA mice cutaneous test, were observed. No alterations in plasma VEGF and AT-III were seen.