Diabetes mellitus type 2(DM2) is characterized by recurrent or persistent hyperglycemia and some alterations of angiogenesis, such as macro and microangiopathy (nephropathy, retinopathy). In our previous study performed with healthy people we have found negative correlation in case of men, between their age and serum in vivo activity, and negative correlation between their age and serum VEGF concentration. In case of women, no such relations were observed. The aim of the present study was to evaluate total in vivo angiogenic activity as well as a concentration of VEGF in sera collected from 40 healthy and 64 DM2 people of various age (40-90 years old), and to establish whether some correlation exists between studied parameters and persons sex. We have found for women higher DM2 sera angiogenic activity than the activity of sera collected from DM2 men and healthy women. Similarly, VEGF content was the highest in the sera collected from DM2 women.