The interaction between inflammatory and endothelial cells seem to play a crucial role in the development of late vascular diabetic complications. The aim of our study was to evaluate the level of CRP and some markers of endothelial function in type 1 diabetic patients. Moreover, we assessed the relationship between CRP and those markers: endothelin-1 (ET-1), metabolites of nitric oxide (NO2&#8211;), soluble form of Intercellular Cell Adhesion Molecule-1 (sICAM-1), Vascular Cell Adhesion Molecule-1 (sVCAM-1), sE-selectin, fibronectin and von Willebrand factor (vWF). The study was performed in 98 type 1 diabetic patients (57 women and 41 men), aged 32.1&plusmn;9.8 years, duration of disease 12.8&plusmn;7.4 years and HbA1c 7.8&plusmn;2.6%. Serum levels of CRP, ET-1, sICAM-1, sVCAM-1, sE-selectin, fibronectin, metabolite of NO and vWF were estimated using ELISA commercial test. CRP, ET-1, NO2&#8211;, sICAM-1, sVCAM-1, vWF, sE-selectin and fibronectin were significantly higher in diabetic patients in comparison with healthy subjects (p<0.05). CRP and NO2&#8211; were markedly higher in diabetic patients with microangiopathy (CRP: 4.91&plusmn;0.28 vs 2.33&plusmn;0.28 mg/l, p<0.05; NO2&#8211;: 85.49&plusmn;1.71 vs 55.48&plusmn;3.59 &micro;mol/l, p<0.05). Moreover, we noticed positive correlation between CRP and markers of endothelial dysfunction, except the level of sVCAM-1 and sE-selectin (p<0.05). The results of this study might suggest association between inflammatory process and endothelial dysfunction in diabetes.