The paper presents the characteristic of RHDV virus determining the main threat to domestic and wild rabbits. It characterizes the RHDV entering to rabbit’s organism way and describes pathogenesis of rabbits’ plague as well as biological features that differ particular well known RHDV strains. There has been both immunogenity among RHDV strains and their hematological reactivity described. There has been presented diagnostic methods of disease caused by RHDV - the germ that induces symptoms similar to viral hemorrhagic fever (VHF) viruses and viruses that are the reason human hepatitis.