Ketoprofen and diclofenac, which belong to the group of nonsteroidal anti-inflammatory drugs (NSAIDs), are widely used mediactions due to their well known anti-inflammatory effect. Most adverse reactions to these drugs are associated with gastroinstestinal track and kidney, moreover, numerous date indicate that also topical use of ketoprofen and diclofenac may lead to side effects, especially to photosensitivity reactions. Photosensitivity includes common phototoxic reaction as well as much more rare photoallergic reaction, which is an example of delayed T cell mediated hypersensitivity. Useful methods to diagnose photosensitivity reaction include patch testing and photopatch testing. The aim of this study was to present up-to-date knowledge on patomechanism of NSAID-induced photosensitivity, their clinical manifestations and management including recommendations of European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP). The authors also report 4 cases of suggestive photoallergic contact dermatitis after topical use of NSAID in patients diagnosed and treated in the Department of Dermatology, Poznan University of Medical Sciences, together with photographic documentation.