Concentration of haptoglobin (Hp) was measured in 325 goat serum samples using guaiacol (peroxidase) test. One hundred forty six samples (45%) originated from goats infected with small ruminant lentivirus (SRLV), etiological agent of caprine arthritis-encephalitis (CAE), whereas 179 (55%) from non-infected goats. Mann-Whitney U test was applied to evaluate statistical significance of a difference between Hp concentrations in CAE-positive and CAE-negative sera. Totally, 11 serum samples were positive for Hp – 4 CAE-positive (2.7%) and 7 CAE-negative (3.9%). Hp concentrations in 4 CAE-positive samples were 0.17, 0.83, 1.28, 9.25 g/l, whereas Hp concentrations in remaining 7 CAE-negative serum samples were 0.11, 0.16, 0.19, 0.49, 0.62, 0.91 and 1.21 g/l. No statistically significant difference between Hp concentrations in CAE-positive and CAE-negative sera could be found. However median of Hp concentrations in goats with detectable levels of Hp in the former group (1.06 g/l) was more than 2-fold higher than in the latter group (0.49 g/l).