Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Share:
Send email
Share:
Original paper

p65 enhanced METTL3-mediated m6A methylation of HMGB1 to promote microglia M1 polarization in sepsis-associated encephalopathy

Xiaowen Wu
1
,
Jie Wang
2
,
Jun Li
1
,
Guosheng Yao
1
,
Linyun Wei
1
,
Xuebin Li
3, 4, 5

  1. Department of Intensive Care Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China
  2. Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China
  3. Department of Neurology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China
  4. School of Clinical Medicine, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China
  5. Biological Molecule Laboratory, Guangxi University Key Laboratory of High Incidence Prevention and Control Research in Western Guangxi, Baise, Guangxi, China
Cent Eur J Immunol 2025; 50 (4)
DOI: https://doi.org/10.5114/ceji.2025.154882
Online publish date: 2025/10/21
Article file
- p65 enhanced.pdf  [4.51 MB]
Get citation
 
PlumX metrics:
 
1. Chung HY, Wickel J, Hahn N, et al. (2023): Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy. Sci Adv 9: eabq7806.
2. Mazeraud A, Righy C, Bouchereau E, et al. (2020): Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17: 392-403.
3. Catarina AV, Branchini G, Bettoni L, et al. (2021): Sepsis-associated encephalopathy: from pathophysiology to progress in experimental studies. Mol Neurobiol 58: 2770-2779.
4. Castro LVG, Goncalves-de-Albuquerque CF, Silva AR (2022): Polarization of microglia and its therapeutic potential in sepsis. Int J Mol Sci 23: 4925.
5. Hu J, Xie S, Zhang H, et al. (2023): Microglial activation: Key players in sepsis-associated encephalopathy. Brain Sci 13: 1453.
6. Qiu F, Zeng C, Liu Y, et al. (2023): J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-kappaB signaling pathway. J Mol Histol 54: 725-738.
7. Min XL, Jia WJ, Guo L, et al. (2024): Brain microvascular endothelial cell-derived exosomes transmitting circ_0000495 promote microglial M1-polarization and endothelial cell injury under hypoxia condition. FASEB J 38: e23387.
8. Mockenhaupt K, Gonsiewski A, Kordula T (2021): RelB and neuroinflammation. Cells 10: 1609.
9. Wang L, Liang Q, Lin A, et al. (2019): Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin. Life Sci 232: 116647.
10. Kikuchi DS, Campos ACP, Qu H, et al. (2019): Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy. J Neuroinflammation 16: 241.
11. Ganbold T, Bao Q, Zandan J, et al. (2020): Modulation of microglia polarization through silencing of NF-kappaB p65 by functionalized curdlan nanoparticle-mediated RNAi. ACS Appl Mater Interfaces 12: 11363-11374.
12. Zhuang H, Yu B, Tao D, et al. (2023): The role of m6A methylation in therapy resistance in cancer. Mol Cancer 22: 91.
13. Wang T, Kong S, Tao M, Ju S (2020): The potential role of RNA N6-methyladenosine in Cancer progression. Mol Cancer 19: 88.
14. Chen P, Liu J, Sun K, et al. (2023): Methylation of TTC4 interaction with HSP70 inhibits pyroptosis in macrophages of sepsis-induced lung injury by NLRP3 inflammation. Am J Cancer Res 13: 5122-5137.
15. Zhu L, Zhang H, Zhang X, Xia L (2024): RNA m6A methylation regulators in sepsis. Mol Cell Biochem 479: 2165-2180.
16. Wang H, Wang Q, Chen J, Chen C (2022): Association among the gut microbiome, the serum metabolomic profile and RNA m(6)A methylation in sepsis-associated encephalopathy. Front Genet 13: 859727.
17. Deng C, Zhao L, Yang Z, et al. (2022): Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury. Acta Pharmacol Sin 43: 520-528.
18. Song H, Zhang X, Zhai R, et al. (2022): Metformin attenuated sepsis-associated liver injury and inflammatory response in aged mice. Bioengineered 13: 4598-4609.
19. Fan H, Tang HB, Chen Z, et al. (2020): Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury. J Neuroinflammation 17: 295.
20. Yin XY, Tang XH, Wang SX, et al. (2023): HMGB1 mediates synaptic loss and cognitive impairment in an animal model of  sepsis-associated encephalopathy. J Neuroinflammation 20: 69.
21. Li PL, Zhai XX, Wang J, et al. (2023): Two ferulic acid derivatives inhibit neuroinflammatory response in human HMC3 microglial cells via NF-kappaB signaling pathway. Molecules 28: 2080.
22. Li Y, Fan Z, Jia Q, et al. (2023): Chaperone-mediated autophagy (CMA) alleviates cognitive impairment by reducing neuronal death in sepsis-associated encephalopathy (SAE). Exp Neurol 365: 114417.
23. Sonneville R, Benghanem S, Jeantin L, et al. (2023): The spectrum of sepsis-associated encephalopathy: a clinical perspective. Crit Care 27: 386.
24. Yang Y, Liang S, Geng J, et al. (2020): Development of a nomogram to predict 30-day mortality of patients with sepsis-associated encephalopathy: a retrospective cohort study. J Intensive Care 8: 45.
25. Dumbuya JS, Li S, Liang L, Zeng Q (2023): Paediatric sepsis-associated encephalopathy (SAE): a comprehensive review. Mol Med 29: 27.
26. Yan X, Yang K, Xiao Q, et al. (2022): Central role of microglia in sepsis-associated encephalopathy: From mechanism to therapy. Front Immunol 13: 929316.
27. Wang H, Wang H, Song Y, et al. (2022): Overexpression of Foxc1 ameliorates sepsis‑associated encephalopathy by inhibiting microglial migration and neuroinflammation through the IkappaBalpha/NF‑kappaB pathway. Mol Med Rep 25: 107.
28. Jiang F, Liu X, Cui X, et al. (2022): Circ_0000518 promotes macrophage/microglia M1 polarization via the FUS/CaMKKbeta/AMPK pathway to aggravate multiple sclerosis. Neuroscience 490: 131-143.
29. Yang S, Yuan Z, Zhu Y, et al. (2024): Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-gamma and PHGDH as a metabolic checkpoint of microglia polarization. Brain Behav Immun 117: 155-166.
30. Wang LL, Wang H, Lin SJ, et al. (2024): ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis. Acta Pharmacol Sin 45: 2077-2091.
31. Liu J, Yue Y, Han D, et al. (2014): A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 10: 93-95.
32. Shen H, Xie K, Li M, et al. (2022): N(6)-methyladenosine (m(6)A) methyltransferase METTL3 regulates sepsis-induced myocardial injury through IGF2BP1/HDAC4 dependent manner. Cell Death Discov 8: 322.
33. Wang D, Qian W, Wu D, et al. (2024): METTL3 promotes microglial inflammation via MEF2C in spinal cord injury. Cell Tissue Res 395: 189-197.
34. Wen L, Sun W, Xia D, et al. (2022): The m6A methyltransferase METTL3 promotes LPS-induced microglia inflammation through TRAF6/NF-kappaB pathway. Neuroreport 33: 243-251.
35. Paudel YN, Shaikh MF, Chakraborti A, et al. (2018): HMGB1: A common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction. Front Neurosci 12: 628.
36. DeWulf B, Minsart L, Verdonk F, et al. (2023): High mobility group box 1 (HMGB1): Potential target in sepsis-associated encephalopathy. Cells 12: 1088.
37. Li M, Hu J, Peng Y, et al. (2021): CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Mol Med 27: 45.
Copyright: © 2025 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.