Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Share:
Share:
Original paper

lncRNA FENDRR targets miR-3614-5p to promote sepsis-induced acute kidney injury via the pro-inflammatory response

Quanan He
1
,
Yiqing Li
2
,
Yanping Peng
3
,
Xiaodan Sun
3
,
Yao Ma
3
,
Xusheng Yang
3
,
Yang Zhao
3
,
Yunxiao Jia
3
,
Yunxing Guo
3
,
Jianping Yi
4

  1. Department of Emergency, Wuhan Brain Hospital, General Hospital of the Yangtze River Shipping, China
  2. Department of Intensive Care Medicine, Xi’an Power Central Hospital of Genertec Guozhong Healthcare Limited Company, China
  3. Department of Nephrology, Beijing Rehabilitation Hospital, Capital Medical School, China
  4. Emergency Department, The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, China
Cent Eur J Immunol 2025; 50
Online publish date: 2025/10/16
Article file
Get citation
 
PlumX metrics:
 
1. Shi C, Zhao Y, Li Q, et al. (2021): lncRNA SNHG14 plays a role in sepsis-induced acute kidney injury by regulating miR-93. Mediators Inflamm 2021: 5318369.
2. Hoste EAJ, Bagshaw SM, Bellomo R, et al. (2015): Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 41: 1411-1423.
3. Yang S, Ye Z, Chen W, et al. (2024): BMAL1 alleviates sepsis-induced AKI by inhibiting ferroptosis. Int Immunopharmacol 142: 113159.
4. Peerapornratana S, Manrique-Caballero CL, Gómez H, et al. (2019): Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int 96: 1083-1099.
5. Verma S, Kellum JA (2021): Defining acute kidney injury. Crit Care Clin 37: 251-266.
6. Molinari L, Heskia F, Peerapornratana S, et al. (2021): Limiting acute kidney injury progression in sepsis: study protocol and trial simulation. Crit Care Med 49: 1706-1716.
7. Chawla LS, Amdur RL, Amodeo S, et al. (2011): The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79: 1361-1369.
8. Jiang ZJ, Zhang MY, Fan ZW, et al. (2019): Influence of lnc-RNA HOTAIR on acute kidney injury in sepsis rats through regulating miR-34a/Bcl-2 pathway. Eur Rev Med Pharmacol Sci 23: 3512-3519.
9. Zhang X, Huang Z, Wang Y, et al. (2021): Long non-coding RNA RMRP contributes to sepsis-induced acute kidney injury. Yonsei Med J 62: 262-273.
10. Li H, Duan J, Zhang T, et al. (2024): miR-16-5p aggravates sepsis-associated acute kidney injury by inducing apoptosis. Ren Fail 46: 2322688.
11. Ge J, Zhang X, Liu Y, et al. (2024): miR-874-3p is identified as a biomarker for acute kidney injury and mediates disease development via targeting MSRB3. Nephron 148: 426-436.
12. Yang N, Yan N, Bai Z, et al. (2024): FTO attenuates LPS-induced acute kidney injury by inhibiting autophagy via regulating SNHG14/miR-373-3p/ATG7 axis. Int Immunopharmacol 128: 111483.
13. Fazaeli H, Sheikholeslami A, Ghasemian F, et al. (2023): The emerging role of lncRNA FENDRR in multiple cancers: a review. Curr Mol Med 23: 606-629.
14. Tawfick A, Matboli M, Shamloul S, et al. (2022): Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy. World J Urol 40: 1561-1567.
15. Cheng L, Nan C, Kang L, et al. (2020): Whole blood transcriptomic investigation identifies long non-coding RNAs as regulators in sepsis. J Transl Med 18: 217.
16. Liang H, Yu T, Han Y, et al. (2018): LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression. Mol Cancer 17: 119.
17. Yang JJ, Wu BB, Han F, et al. (2020): Gene expression profiling of sepsis-associated acute kidney injury. Exp Ther Med 20: 34.
18. Huang W, Wu X, Xue Y, et al. (2021): MicroRNA-3614 regulates inflammatory response via targeting TRAF6-mediated MAPKs and NF-B signaling in the epicardial adipose tissue with coronary artery disease. Int J Cardiol 324: 152-164.
19. Singer M, Deutschman CS, Seymour CW, et al. (2016): The third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama 315: 801-810.
20. Khwaja A (2012): KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract 120: c179-184.
21. Li YM, Zhang J, Su LJ, et al. (2019): Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-b pathway. Biochim Biophys Acta Mol Basis Dis 1865: 558-569.
22. Fan H, Le JW, Sun M, et al. (2021): Pretreatment with S-nitrosoglutathione attenuates septic acute kidney injury in rats by inhibiting inflammation, oxidation, and apoptosis. Biomed Res Int 2021: 6678165.
23. Fan H, Le JW, Zhu JH (2020): Protective effect of N-acetylcysteine pretreatment on acute kidney injury in septic rats. J Surg Res 254: 125-134.
24. Li W, Liu J, Zhao H (2020): Identification of a nomogram based on long non-coding RNA to improve prognosis prediction of esophageal squamous cell carcinoma. Aging (Albany NY) 12: 1512-1526.
25. Ahmadirad H, Pourghadamyari H, Hadizadeh M, et al. (2024): Differential expression of long non-coding RNAs in colon cancer: Insights from transcriptomic analysis. Pathol Res Pract 261: 155477.
26. Si Y, Sun B, Huang Y, et al. (2024): Predictive value of red cell distribution width-to-platelet ratio combined with procalcitonin in 28-day mortality for patients with sepsis. Crit Care Res Pract 2024: 9964992.
27. Zhu W, Ou Y, Wang C, et al. (2024): A neutrophil elastase inhibitor, sivelestat, attenuates sepsis-induced acute kidney injury by inhibiting oxidative stress. Heliyon 10: e29366.
28. Ates HC, Alshanawani A, Hagel S, et al. (2024): Unraveling the impact of therapeutic drug monitoring via machine learning for patients with sepsis. Cell Rep Med 101681.
29. Chen Q, Zhan H, Chen J, et al. (2024): Predictive value of lactate/albumin ratio for death and multiple organ dysfunction syndrome in patients with sepsis. J Med Biochem 43: 617-625.
30. Zhou X, He Y, Hu L, et al. (2022): Lactate level and lactate clearance for acute kidney injury prediction among patients admitted with ST-segment elevation myocardial infarction: A retrospective cohort study. Front Cardiovasc Med 9: 930202.
31. Monard C, Rimmelé T, Blanc E, et al. (2023): Economic burden of in-hospital AKI: a one-year analysis of the nationwide French hospital discharge database. BMC Nephrol 24: 343.
32. Wang L, Cao QM (2022): Long non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p/WWC1 axis. Kaohsiung J Med Sci 38: 6-17.
33. Deng LT, Wang QL, Yu C, et al. (2021): lncRNA PVT1 modulates NLRP3‑mediated pyroptosis in septic acute kidney injury by targeting miR‑20a‑5p. Mol Med Rep 23: 271.
34. Xu L, Hu G, Xing P, et al. (2020): Paclitaxel alleviates the sepsis-induced acute kidney injury via lnc-MALAT1/miR-370-3p/HMGB1 axis. Life Sci 262: 118505.
35. Pietrukaniec M, Migacz M, Żak-Gołąb A, et al. (2020): Could KIM-1 and NGAL levels predict acute kidney injury after paracentesis? – preliminary study. Ren Fail 42: 853-859.
36. Ren GL, Zhu J, Li J, et al. (2019): Noncoding RNAs in acute kidney injury. J Cell Physiol 234: 2266-2276.
37. Pan T, Jia P, Chen N, et al (2019): Delayed remote ischemic preconditioning ConfersRenoprotection against septic acute kidney injury via exosomal miR-21. Theranostics 9: 405-423.
38. Wang M, Wei J, Shang F, et al. (2020): Long non‑coding RNA CASC2 ameliorates sepsis‑induced acute kidney injury by regulating the miR‑155 and NF‑B pathway. Int J Mol Med 45: 1554-1562.
39. Wang J, Chen J, Li Z, et al. (2024): The negative feedback loop of NF-B/miR-202-5p/HMGB2 attenuates sepsis induced acute kidney injury. Int Immunopharmacol 142: 113050.
Copyright: © 2025 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2025 Termedia Sp. z o.o.
Developed by Bentus.