Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Share:
Share:
Original paper

Paeoniflorin inhibits degranulation of mast cells through suppressing the cGAS/STING signaling pathway

Guanli Song
1
,
Guanbo Song
2
,
Xiaji Zhou
3
,
Lei Zhang
4

  1. Department of Preventive and Health Care, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China
  2. Department of Clinical Laboratory, Jining Chinese Medicine Hospital, Jining, Shandong, P.R. China
  3. Department of Prestigious TCM Doctors’ Experiences, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, P.R. China
  4. National Data Center of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, P.R. China
Cent Eur J Immunol 2025; 50 (4)
Online publish date: 2025/08/25
Article file
Get citation
 
PlumX metrics:
 
1. Galli SJ, Tsai M, Piliponsky AM (2008): The development of allergic inflammation. Nature 454: 445-454.
2. Wheatley LM, Togias A (2015): Clinical practice. Allergic rhinitis. N Engl J Med 372: 456-463.
3. Bédard A, Sofiev M, Arnavielhe S, et al. (2020): Interactions between air pollution and pollen season for rhinitis using mobile technology: A MASK-POLLAR Study. J Allergy Clin Immunol Pract 8: 1063-1073.e4.
4. Papapostolou G, Kiotseridis H, Romberg K, et al. (2021): Cognitive dysfunction and quality of life during pollen season in children with seasonal allergic rhinitis. Pediatr Allergy Immunol 32: 67-76.
5. Taylor JA, Karas JL, Ram MK, et al. (1995): Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains. Mol Cell Biol 15: 4149-4157.
6. Shamji MH, Sharif H, Layhadi JA, et al. (2022): Diverse immune mechanisms of allergen immunotherapy for allergic rhinitis with and without asthma. J Allergy Clin Immunol 149: 791-801.
7. Li Y, Leung PSC, Gershwin ME, Song J (2022): New mechanistic advances in FcRI-mast cell–mediated allergic signaling. Clin Rev Allergy Immunol 63: 431-446.
8. McNeil BD, Pundir P, Meeker S, et al. (2015): Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature 519: 237-241.
9. Wang XZ, Xia L, Zhang XY, et al. (2022): The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art. Biomed Pharmacother 149: 112800.
10. Liu HQ, Zhang WY, Luo XT, et al. (2006): Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease by activation of adenosine A1 receptor. Br J Pharmacol 148: 314-325.
11. Peng W, Chen Y, Tumilty S, et al. (2022): Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis. Curr Opin Pharmacol 62: 97-102.
12. Tang M, Chen M, Li Q (2021): Paeoniflorin ameliorates chronic stress-induced depression-like behavior in mice model by affecting ERK1/2 pathway. Bioengineered 12: 11329-11341.
13. Lei C, Chen Z, Fan L, et al. (2022): Integrating metabolomics and network analysis for exploring the mechanism underlying the antidepressant activity of paeoniflorin in rats with CUMS-induced depression. Front Pharmacol 13: 904190.
14. Wang XL, Wang YT, Guo ZY, et al. (2022): Efficacy of paeoniflorin on models of depression: A systematic review and meta-analysis of rodent studies. J Ethnopharmacol 290: 115067.
15. Li PP, Liu DD, Liu YJ, et al. (2012): BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol 141: 290-300.
16. Shou Q, Jin L, Lang J, et al. (2018): Integration of metabolomics and transcriptomics reveals the therapeutic mechanism underlying paeoniflorin for the treatment of allergic asthma. Front Pharmacol 9: 1531.
17. Yang H, Song L, Sun B, et al. (2021): Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing. Mater Today Bio 12: 100139.
18. Zhang L, Wei W (2020): Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther 207: 107452.
19. Zhao Y, Li X, Chu J, et al. (2021): Inhibitory effect of paeoniflorin on IgE-dependent and IgE-independent mast cell degranulation in vitro and vivo. Food Funct 12: 7448-7468.
20. Morante-Palacios O, Lorente-Sorolla C, Ciudad L, et al. (2021): JAK2-STAT epigenetically regulates tolerized genes in monocytes in the first encounter with gram-negative bacterial endotoxins in sepsis. Front Immunol 12: 734652.
21. Zhang Q, Peng W, Wei S, et al. (2019): Guizhi-Shaoyao-Zhimu decoction possesses anti-arthritic effects on type II collagen-induced arthritis in rats via suppression of inflammatory reactions, inhibition of invasion & migration and induction of apoptosis in synovial fibroblasts. Biomed Pharmacother 118: 109367.
22. He L, Du J, Chen Y, et al. (2019): Renin-angiotensin system promotes colonic inflammation by inducing T(H)17 activation via JAK2/STAT pathway. Am J Physiol Gastrointest Liver Physiol 316: G774-G784.
23. Shi Z, Jiang W, Wang M, et al. (2017): Inhibition of JAK/STAT pathway restrains TSLP-activated dendritic cells mediated inflammatory T helper type 2 cell response in allergic rhinitis. Mol Cell Biochem 430: 161-169.
24. Li A, Zhao F, Zhao Y, et al. (2021): ATF4-mediated GDF15 suppresses LPS-induced inflammation and MUC5AC in human nasal epithelial cells through the PI3K/Akt pathway. Life Sci 275: 119356.
25. Marok R, Winyard PG, Coumbe A, et al. (1996): Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum 39: 583-591.
26. Viatour P, Merville MP, Bours V, Chariot A (2005): Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci 30: 43-52.
27. Decout A, Katz JD, Venkatraman S, Ablasser A (2021): The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol 21: 548-569.
28. McNeil BD, Pundir P, Meeker S, et al. (2015): Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature (London) 519: 237-241.
29. Reite OB (1972): Comparative physiology of histamine. Physiol Rev 52: 778.
30. Howarth PH, Salagean M, Dokic D (2000): Allergic rhinitis: not purely a histamine-related disease. Allergy 55: 7-16.
31. Steelant B, Seys SF, Van Gerven L, et al. (2018): Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis. J Allergy Clin Immunol 141: 951-963.e8.
32. Wernersson S, Pejler G, Sveriges L (2014): Mast cell secretory granules: armed for battle. Nat Rev Immunol 14: 478-494.
33. Cheong H, Ryu SY, Kim KM (1999): Anti-allergic action of resveratrol and related hydroxystilbenes. Planta Med 65: 266-268.
34. Kang B, Kim M, Lee S, et al. (2019): Nothofagin suppresses mast cell-mediated allergic inflammation. Chem Biol Interact 298: 1-7.
35. Wu X, Qi X, Wang J, et al. (2021): Paeoniflorin attenuates the allergic contact dermatitis response via inhibiting the IFN- production and the NF-B/IB signaling pathway in T lymphocytes. Int Immunopharmacol 96: 107687-107687.
36. Guo J, Peng L, Zeng J, et al. (2021): Paeoniflorin suppresses allergic and inflammatory responses by promoting autophagy in rats with urticaria. Exp Ther Med 21: 590.
37. Wang C, Yuan J, Wu H, et al. (2013): Paeoniflorin inhibits inflammatory responses in mice with allergic contact dermatitis by regulating the balance between inflammatory and anti-inflammatory cytokines. Inflamm Res 62: 1035-1044.
38. Sun J, Wu J, Xu C, et al. (2015): Paeoniflorin attenuates allergic inflammation in asthmatic mice. Int Immunopharmacol 24: 88-94.
39. Koopmans T, Anaparti V, Castro-Piedras I, et al. (2014): Ca2+ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting. Pulm Pharmacol Ther 29: 108-120.
40. Wang J, Zhang Y, Wang J, et al. (2020): Paeoniflorin inhibits MRGPRX2-mediated pseudo-allergic reaction via calcium signaling pathway. Phytother Res 34: 401-408.
41. Wang Y, Luo J, Alu A, et al. (2020): cGAS-STING pathway in cancer biotherapy. Mol Cancer 19: 136.
42. Jiang M, Chen P, Wang L, et al. (2020): cGAS-STING, an important pathway in cancer immunotherapy. J Hematol Oncol 13: 81.
43. Zierhut C, Yamaguchi N, Paredes M, et al. (2019): The cytoplasmic DNA sensor cGAS promotes mitotic cell death. Cell 178: 302-315.e23.
44. Brault M, Olsen TM, Martinez J, et al. (2018): Intracellular nucleic acid sensing triggers necroptosis through synergistic type I IFN and TNF signaling. J Immunol 200: 2748-2756.
45. Tang CA, Zundell JA, Ranatunga S, et al. (2016): Agonist-mediated activation of STING induces apoptosis in malignant B cells. Cancer Res 76: 2137-2152.
46. Wang G, Cheng N (2018): Paeoniflorin inhibits mast cell-mediated allergic inflammation in allergic rhinitis. J Cell Biochem 119: 8636-8642.
Copyright: © 2025 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2025 Termedia Sp. z o.o.
Developed by Bentus.