Central European Journal of Immunology
eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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abstract:
Original paper

Intestinal CD8+ γδ T cells shift from immune activation to suppression, with concomitant impairment of cytotoxicity as disease activity increases in patients with ulcerative colitis

Jia Zhu
1
,
Tao Zhu
1
,
Caixia Sheng
1
,
Tingting Zhong
1
,
Jiaqi Xu
1
,
Xiaoqing Cheng
1
,
Jin Wang
1
,
Guoxiang Fu
1
,
Zhinong Jiang
1
,
Yujie Jiang
1

  1. Sir Run Run Shaw Hospital, affiliated with Zhejiang University School of Medicine, China
Cent Eur J Immunol 2025; 50
DOI: https://doi.org/10.5114/ceji.2025.153773
Online publish date: 2025/10/09
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Introduction
Ulcerative colitis (UC) is a persistent inflammatory intestinal condition characterized by fluctuating disease activity (DA), with incompletely understood immunopathogenesis.

Material and methods
Our analysis included employing flow cytometry to examine CD8+ γδ T cells in the intestinal mucosa (IM) and the peripheral blood (PB) of UC patients as well as healthy controls. We focused on the presence of the HLA-DR activation indicator, the PD-1 immune suppression component, and the cytotoxic elements TRAIL, granzyme B, and perforin within CD8+ γδ T cells.

Results
A marked decline in the levels of IM CD8+ γδ T cells with increasing UC DA was observed. The immune status of these cells transitioned from activation in individuals with moderate UC activity to suppression in those experiencing severe UC activity. Correspondingly, cytotoxicity, indicated by granzyme B and perforin levels, was impaired in patients with severe UC activity. Notably, the proportions of IM CD8+ γδ T cells expressing granzyme B, PD-1, and HLA-DR were identified as potential biomarkers for distinguishing disease severity.

Conclusions
Our findings demonstrate the progression from immune activation to suppression and the concomitant impairment of cytotoxic activity in intestinal CD8+ γδ T cells as DA increases in UC, which may have implications for disease monitoring and therapeutic intervention.

keywords:

ulcerative colitis, CD8+ γδ T cells, disease activity, immune status, cytotoxicity
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